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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Peiminine, Doxorubicin
Phytochemical Name Peiminine (PubChem CID: 167691 )
Anticancer drug Name Doxorubicin (PubChem CID: 31703 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 42
Ref_1
Pair Name Peiminine, Doxorubicin
Disease Info [ICD-11: 2B72.Z] Gastric cancer Investigative
Gene Regulation Down-regulation Expression CCND1 hsa595
Up-regulation Cleavage PARP1 hsa142
Down-regulation Expression EGFR hsa1956
Down-regulation Expression PTK2 hsa5747
In Vitro Model SGC-7901 Human papillomavirus-related cervical adenocarcinoma Homo sapiens (Human) CVCL_0520
Result Our findings indicated that sinapine played an important role in the downregulation of MDR1 expression through suppression of fibroblast growth factor receptor (FGFR)4/FRS2α-ERK1/2 mediated NF-κB activation in MCF-7/dox cancer cells.
03. Reference
No. Title Href
1 Peiminine serves as an adriamycin chemosensitizer in gastric cancer by modulating the EGFR/FAK pathway. Oncol Rep. 2018 Mar;39(3):1299-1305. doi: 10.3892/or.2018.6184. Click
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